Translational Therapeutics and Diagnostics for Alzheimer's Disease

The distribution of muscarinic M1 receptors in the human hippocampus

E Scarr, MS Seo, TD Aumann, G Chana, IP Everall, B Dean

2016-11-01

The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions suc..

Neurological Dysfunction in Early Maturity of a Model for Niemann–Pick C1 Carrier Status

YH Hung, M Walterfang, L Churilov, L Bray, LH Jacobson, KJ Barnham, NC Jones, TJ O’Brien, D Velakoulis, AI Bush

2016-07-01

Autosomal recessive inheritance of NPC1 with loss-of-function mutations underlies Niemann–Pick disease, type C1 (NP-C1), a lysosom..

Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia

E Scarr, M Udawela, MA Greenough, J Neo, MS Seo, TT Money, A Upadhyay, AI Bush, IP Everall, EA Thomas, B Dean

2016-03-09

Our expression microarray studies showed messenger RNA (mRNA) for solute carrier family 39 (zinc transporter), member 12 (SLC39A12..

φxANES: In vivo imaging of metal-protein coordination environments

SA James, DJ Hare, NL Jenkins, MD De Jonge, AI Bush, G McColl

2016-02-10

We have developed an X-ray absorption near edge structure spectroscopy method using fluorescence detection for visualizing in vivo..

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

DJ Hare, MWM Jones, VC Wimmer, NL Jenkins, MD De Jonge, AI Bush, G McColl

2016-02-01

Here, we present a sub-μm multimodal approach to image essential elements in Caenorhabditis elegans. A combination of chemical ima..

Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons

A BUSH, AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, KJ Barnham, JA Duce, RA Cherny

2016-01-01

Pyroglutamate-modified amyloid- (pΕ-Aβ) is a highly neurotoxic amyloid-β (Aβ) isoform and is enriched in the brains of individuals..

Erratum: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (Chem. Sci. (2015) DOI:10.1039/c5sc02231b)

B Paul, DJ Hare, DP Bishop, C Paton, VT Nguyen, N Cole, MM Niedzwiecki, E Andreozzi, A Vais, JL Billings, L Bray, AI Bush, G McColl, BR Roberts, PA Adlard, DI Finkelstein, J Hellstrom, JM Hergt, JD Woodhead, PA Doble

2015-09-10

Correction for 'Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-..

Is early-life iron exposure critical in neurodegeneration?

DJ Hare, M Arora, NL Jenkins, DI Finkelstein, PA Doble, AI Bush

2015-09-07

The effects of iron deficiency are well documented, but relatively little is known about the long-term implications of iron overlo..

Metal chaperones prevent zinc-mediated cognitive decline

PA Adlard, J Parncutt, V Lal, S James, D Hare, P Doble, DI Finkelstein, AI Bush

2015-09-01

Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availabi..

Selenium, selenoproteins and neurodegenerative diseases

BR Cardoso, BR Roberts, AI Bush, DJ Hare

2015-08-01

It is unsurprising that our understanding of the role of selenium in neurological function is somewhat immature, considering its r..

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

SA James, BR Roberts, DJ Hare, MD De Jonge, IE Birchall, NL Jenkins, RA Cherny, AI Bush, G McColl

2015-05-01

Iron is essential for eukaryotic biochemistry. Systematic trafficking and storage is required to maintain supply of iron while pre..

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease

KL Berggren, J Chen, J Fox, J Miller, L Dodds, B Dugas, L Vargas, A Lothian, E McAllum, I Volitakis, B Roberts, AI Bush, JH Fox

2015-04-01

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamin..

Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation

DJ Hare, JD Doecke, NG Faux, A Rembach, I Volitakis, CJ Fowler, R Grimm, PA Doble, RA Cherny, CL Masters, AI Bush, BR Roberts

2015-03-18

Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding pl..

Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia

M Rapado-Castro, M Berk, K Venugopal, AI Bush, S Dodd, OM Dean

2015-03-03

Schizophrenia is a chronic and often debilitating disorder in which stage of illness appears to influence course, outcome, prognos..

Follow-up plasma apolipoprotein e levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort

VB Gupta, AC Wilson, S Burnham, E Hone, S Pedrini, SM Laws, WLF Lim, A Rembach, S Rainey-Smith, D Ames, L Cobiac, SL MacAulay, CL Masters, CC Rowe, AI Bush, RN Martins

2015-02-20

Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devast..

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

S Ayton, P Lei, AI Bush

2015-01-01

No disease modifying therapy exists for Alzheimer’s disease (AD). The growing burden of this disease to our society necessitates c..

High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer

E Robb, K Perez, LW Hung, CL Masters, KJ Barnham, RA Cherny, AI Bush, PA Adlard, DI Finkelstein

2015-01-01

Oligomeric forms of amyloid-β (Aβ) are thought to be responsible for the pathogenesis of Alzheimer's disease. While many oligomers..

Parkinson’s disease iron deposition caused by nitric oxide- induced loss of β-amyloid precursor protein

X Ayton, X Lei, XJ Hare, JA Duce, JL George, PA Adlard, C McLean, JT Rogers, RA Cherny, DI Finkelstein, XI Bush

2015-01-01

Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson’s disease (PD) pathoge..

Traumatic brain injury induces elevation of Co in the human brain

2015-01-01

Traumatic brain injury (TBI) is the most common cause of death and disability in young adults, yet the molecular mechanisms that f..

β-amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin

BX Wong, A Tsatsanis, LQ Lim, PA Adlard, AI Bush, JA Duce

2014-12-02

Ceruloplasmin is a ferroxidase that interacts with ferroportin to export cellular iron, but is not expressed in neurons. We recent..

An anemia of Alzheimer's disease

NG Faux, A Rembach, J Wiley, KA Ellis, D Ames, CJ Fowler, RN Martins, KK Pertile, RL Rumble, B Trounson, CL Masters, AI Bush

2014-11-05

Lower hemoglobin is associated with cognitive impairment and Alzheimer's disease (AD). Since brain iron homeostasis is perturbed i..

Influence of BDNF Val66Met on the relationship between physical activity and brain volume

BM Brown, P Bourgeat, JJ Peiffer, S Burnham, SM Laws, SR Rainey-Smith, D Bartrés-Faz, VL Villemagne, K Taddei, A Rembach, A Bush, KA Ellis, SL MacAulay, CC Rowe, D Ames, CL Masters, P Maruff, RN Martins

2014-10-01

Objective: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the inter..

Motor and cognitive deficits in aged tau knockout mice in two background strains

P Lei, S Ayton, S Moon, Q Zhang, I Volitakis, DI Finkelstein, AI Bush

2014-08-14

Background: We recently reported that Parkinsonian and dementia phenotypes emerge between 7-12 months of age in tau^-/-m..

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: Implications for Parkinson's disease

S Ayton, P Lei, PA Adlard, I Volitakis, RA Cherny, AI Bush, DI Finkelstein

2014-07-10

Background: The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and path..

Response to comment on Moore et al. Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes care 2013;36:2981-2987

EM Moore

2014-06-01

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron

S Ayton, M Zhang, BR Roberts, LQ Lam, M Lind, C McLean, AI Bush, T Frugier, PJ Crack, JA Duce

2014-04-01

Traumatic brain injury (TBI) is in part complicated by pro-oxidant iron elevation independent of brain hemorrhage. Ceruloplasmin (..

Altered transition metal homeostasis in Niemann-Pick disease, type C1

YH Hung, NG Faux, DW Killilea, N Yanjanin, S Firnkes, I Volitakis, G Ganio, M Walterfang, C Hastings, FD Porter, DS Ory, AI Bush

2014-03-01

The loss of NPC1 protein function is the predominant cause of Niemann-Pick type C1 disease (NP-C1), a systemic and neurodegenerati..

Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal alzheimer's disease: A preliminary study

YY Lim, VL Villemagne, SM Laws, D Ames, RH Pietrzak, KA Ellis, K Harrington, P Bourgeat, AI Bush, RN Martins, CL Masters, CC Rowe, P Maruff

2014-01-27

Objective: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-deriv..

A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: Results from the AIBL study

SC Burnham, NG Faux, W Wilson, SM Laws, D Ames, J Bedo, AI Bush, JD Doecke, KA Ellis, R Head, G Jones, H Kiiveri, RN Martins, A Rembach, CC Rowe, O Salvado, SL Macaulay, CL Masters, VL Villemagne

2014-01-01

Dementia is a global epidemic with Alzheimer's disease (AD) being the leading cause. Early identification of patients at risk of d..

A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2 under physiologically relevant conditions

BX Wong, S Ayton, LQ Lam, P Lei, PA Adlard, AI Bush, JA Duce

2014-01-01

Background Iron oxidation is thought to be predominantly handled enzymatically in the body, to minimize spontaneous combustion wit..

Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model

Z Lu, E Marks, J Chen, J Moline, L Barrows, M Raisbeck, I Volitakis, RA Cherny, V Chopra, AI Bush, S Hersch, JH Fox

2014-01-01

Disruption of redox homeostasis is a prominent feature in the pathogenesis of Huntington's disease (HD). Selenium an essential ele..

An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation

A Rembach, AD Watt, WJ Wilson, S Rainey-Smith, KA Ellis, CC Rowe, VL Villemagne, SL Macaulay, AI Bush, RN Martins, D Ames, CL Masters, JD Doecke

2014-01-01

Inflammation is a hallmark of Alzheimer's disease (AD). Whether directly involved in the pathogenesis, or a downstream consequence..

An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

DJ Hare, P Lei, S Ayton, BR Roberts, R Grimm, JL George, DP Bishop, AD Beavis, SJ Donovan, G McColl, I Volitakis, CL Masters, PA Adlard, RA Cherny, AI Bush, DI Finkelstein, PA Doble

2014-01-01

The co-localization of iron and dopamine raises the risk of a potentially toxic reaction. Disturbance of the balance in this uniqu..

A novel approach to rapidly prevent age-related cognitive decline

PA Adlard, A Sedjahtera, L Gunawan, L Bray, D Hare, J Lear, P Doble, AI Bush, DI Finkelstein, RA Cherny

2014-01-01

Summary: The loss of cognitive function is a pervasive and often debilitating feature of the aging process for which there are no ..

A review of β-amyloid neuroimaging in Alzheimer's disease

PA Adlard, BA Tran, DI Finkelstein, PM Desmond, LA Johnston, AI Bush, GF Egan

2014-01-01

Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing age is the greatest risk factor for developi..

Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease

G Verdile, SM Laws, D Henley, D Ames, AI Bush, KA Ellis, NG Faux, VB Gupta, QX Li, CL Masters, KE Pike, CC Rowe, C Szoeke, K Taddei, VL Villemagne, RN Martins

2014-01-01

Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism...

Biological metals and metal-targeting compounds in major neurodegenerative diseases

KJ Barnham, AI Bush

2014-01-01

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in age-related neurodegenerative disorders..

Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease

A Rembach, NG Faux, AD Watt, KK Pertile, RL Rumble, BO Trounson, CJ Fowler, BR Roberts, KA Perez, QX Li, SM Laws, K Taddei, S Rainey-Smith, JS Robertson, M Vandijck, H Vanderstichele, KJ Barnham, KA Ellis, C Szoeke, L MacAulay

2014-01-01

Background: A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD). Methods: Plasma..

Copper: From neurotransmission to neuroproteostasis

CM Opazo, MA Greenough, AI Bush

2014-01-01

Copper is critical for the Central Nervous System (CNS) development and function. In particular, different studies have shown the ..

Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: Modulation of synaptic activity in hippocampal neurons

PA Castro, A Ramirez, FJ Sepúlveda, C Peters, H Fierro, J Waldron, S Luza, J Fuentealba, FJ Muñoz, GV De Ferrari, AI Bush, LG Aguayo, C Opazo

2014-01-01

Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality an..

Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

ND Barnard, AI Bush, A Ceccarelli, J Cooper, CA de Jager, KI Erickson, G Fraser, S Kesler, SM Levin, B Lucey, MC Morris, R Squitti

2014-01-01

Risk of developing Alzheimer's disease is increased by older age, genetic factors, and several medical risk factors. Studies have ..

Meta-analysis of serum non-ceruloplasmin copper in Alzheimer's disease

R Squitti, I Simonelli, M Ventriglia, M Siotto, P Pasqualetti, A Rembach, J Doecke, AI Bush

2014-01-01

The fraction of copper not bound to ceruloplasmin seems altered in Alzheimer's disease (AD). We have addressed this notion evaluat..

Metals and cholesterol: Two sides of the same coin in Alzheimer's disease pathology

BX Wong, YH Hung, AI Bush, JA Duce

2014-01-01

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, s..

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β

M Yu, TM Ryan, S Ellis, AI Bush, JA Triccas, PJ Rutledge, MH Todd

2014-01-01

Interactions between amyloid β (Aβ) and metal ions are thought to mediate the neuropathogenic effects of Aβ in Alzheimer's disease..

Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

BR Roberts, NKH Lim, EJ McAllum, PS Donnelly, DJ Hare, PA Doble, BJ Turner, KA Price, SC Lim, BM Paterson, JL Hickey, TW Rhoads, JR Williams, KM Kanninen, LW Hung, JR Liddell, A Grubman, JF Monty, RM Llanos, DR Kramer

2014-01-01

Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expr..

Plasma amyloid-β levels are significantly associated with a transition toward alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden

A Rembach, AD Watt, WJ Wilson, VL Villemagne, SC Burnham, KA Ellis, P Maruff, D Ames, CC Rowe, SL MacAulay, AI Bush, RN Martins, CL Masters, JD Doecke

2014-01-01

Background: We evaluated the utility of longitudinal measures of plasma amyloid-β (Aβ) as a means to identify pre-symptomatic cogn..

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

GD Ciccotosto, SA James, M Altissimo, D Paterson, S Vogt, B Lai, MD De Jonge, DL Howard, AI Bush, R Cappai

2014-01-01

The amyloid precursor protein (APP) gene family includes APP and the amyloid precursor-like proteins, APLP1 and APLP2. These prote..

The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

DJ Hare, JL George, L Bray, I Volitakis, A Vais, TM Ryan, RA Cherny, AI Bush, CL Masters, PA Adlard, PA Doble, DI Finkelstein

2014-01-01

Aldehyde preservation of tissue and cryoprotection by sugars and polyols has traditionally been used in histology to preserve stru..

β-amyloid in biological samples: Not all Aβ detection methods are created equal

PA Adlard, QX Li, C McLean, CL Masters, AI Bush, M Fodero-Tavoletti, V Villemagne, KJ Barnham

2014-01-01

Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer's disease.

P Maruff, YY Lim, D Darby, KA Ellis, RH Pietrzak, PJ Snyder, AI Bush, C Szoeke, A Schembri, D Ames, CL Masters

2013-12-23

Background: Previous studies have demonstrated the utility and sensitivity of the CogState Brief Battery (CBB) in detecting cognit..

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

DJ Hare, A Grubman, TM Ryan, A Lothian, JR Liddell, R Grimm, T Matsuda, PA Doble, RA Cherny, AI Bush, AR White, CL Masters, BR Roberts

2013-12-01

Metals often determine the chemical reactivity of the proteins to which they are bound. Each cell in the body tightly maintains a ..

Decreased copper in alzheimer's disease brain is predominantly in the soluble extractable fraction

A Rembach, DJ Hare, M Lind, CJ Fowler, RA Cherny, C McLean, AI Bush, CL Masters, BR Roberts

2013-11-18

Alzheimer's disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. T..

BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease

YY Lim, VL Villemagne, SM Laws, D Ames, RH Pietrzak, KA Ellis, KD Harrington, P Bourgeat, O Salvado, D Darby, PJ Snyder, AI Bush, RN Martins, CL Masters, CC Rowe, PJ Nathan, P Maruff

2013-11-01

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related ..

Erratum: The AIBL Investigators. Increased risk of cognitive impairment in patients with diabetes is associated with metformin (Diabetes Care (2013) 36 (2981-2987))

EM Moore, AG Mander, D Ames, MA Kotowicz, RP Carne, H Brodaty, M Woodward, K Boundy, KA Ellis, AI Bush, NG Faux, R Martins, C Szoeke, C Rowe., DA Watters

2013-11-01

Metallostasis in Alzheimer's disease and Parkinson's disease

A Bush

2013-11-01

Iron Accumulates in Huntington's Disease Neurons: Protection by Deferoxamine

J Chen, E Marks, B Lai, Z Zhang, JA Duce, LQ Lam, I Volitakis, AI Bush, S Hersch, JH Fox

2013-10-11

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-encoding CAG expansion in the hunt..

Increased risk of cognitive impairment in patients with diabetes is associated with metformin

EM Moore, AG Mander, D Ames, MA Kotowicz, RP Carne, H Brodaty, M Woodward, K Boundy, KA Ellis, AI Bush, NG Faux, R Martins, C Szoeke, C Rowe, DA Watters

2013-10-01

OBJECTIVE To investigate the associations of metformin, serum vitamin B12, calciumsupplements, and cognitive impairment in patient..

Links between copper and cholesterol in Alzheimer's disease

YH Hung, AI Bush, SL Fontaine

2013-09-17

Altered copper homeostasis and hypercholesterolemia have been identified independently as risk factors for Alzheimer's disease (AD..

A delicate balance: Iron metabolism and diseases of the brain

D Hare, S Ayton, A Bush, P Lei

2013-09-11

Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransm..

Deserves a hearing? A case report of remitting tinnitus with N-acetyl cysteine

OM Dean, S Jeavons, GS Malhi, SM Cotton, M Tanious, null Kohlmann, K Hewitt, K Moss, C Allwang, I Schapkaitz, J Robbins, H Cobb, S Dodd, A Bush, M Berk

2013-09-04

Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing.

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, A Bush, KA Ellis, CL Masters, D Ames, SL Macaulay, C Szoeke, CC Rowe, RN Martins

2013-08-01

Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic..

Physical activity and amyloid-β plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

BM Brown, JJ Peiffer, K Taddei, JK Lui, SM Laws, VB Gupta, T Taddei, VK Ward, MA Rodrigues, S Burnham, SR Rainey-Smith, VL Villemagne, A Bush, KA Ellis, CL Masters, D Ames, SL MacAulay, C Szoeke, CC Rowe, RN Martins

2013-08-01

Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic..

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

MA Cater, HB Pearson, K Wolyniec, P Klaver, M Bilandzic, BM Paterson, AI Bush, PO Humbert, S La Fontaine, PS Donnelly, Y Haupt

2013-07-19

The therapeutic efficacy of two bis(thiosemicarbazonato) copper complexes, glyoxalbis[N4-methylthiosemicarbazonato]Cu^II..

A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania

PV Da Silva Magalhães, OM Dean, AI Bush, DL Copolov, GS Malhi, K Kohlmann, S Jeavons, I Schapkaitz, M Anderson-Hunt, M Berk

2013-06-01

Objective: Oxidative imbalance has emerged as a treatment target in bipolar disorder. As very limited data are available on the cl..

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

SA James, MD De Jonge, DL Howard, AI Bush, D Paterson, G McColl

2013-06-01

Metals are essential in biochemistry, with highly regulated localisation and concentration. To continue elucidating the impact of ..

The effect of dopamine on MPTP-induced rotarod disability

S Ayton, JL George, PA Adlard, AI Bush, RA Cherny, DI Finkelstein

2013-05-24

Dopamine depletion in Parkinson's disease (PD) results in bradykinesia and tremor. Therapeutic administration of the dopamine prec..

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

S Ayton, P Lei, JA Duce, BXW Wong, A Sedjahtera, PA Adlard, AI Bush, DI Finkelstein

2013-04-01

Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia. We found a ∼80% loss of cerulop..

Metal dyshomeostasis and oxidative stress in Alzheimer's disease

MA Greenough, J Camakaris, AI Bush

2013-04-01

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two pathological hallmarks; the accumulation..

Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels

JA Duce, S Ayton, AA Miller, A Tsatsanis, LQ Lam, L Leone, JE Corbin, H Butzkueven, TJ Kilpatrick, JT Rogers, KJ Barnham, DI Finkelstein, AI Bush

2013-02-01

The catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) are neurotransmitters and hormones that mediate stress r..

Cognitive consequences of high aβ amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease

Y Ying Lim, KA Ellis, K Harrington, A Kamer, RH Pietrzak, AI Bush, D Darby, RN Martins, CL Masters, CC Rowe, G Savage, C Szoeke, VL Villemagne, D Ames, P Maruff

2013-01-01

Background: It has been proposed that only mild cognitive impairment (MCI) with high Aβ amyloid is indicative of incipient Alzheim..

Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: Prodromal Alzheimer's disease?

YY Lim, KA Ellis, K Harrington, RH Pietrzak, J Gale, D Ames, AI Bush, D Darby, RN Martins, CL Masters, CC Rowe, G Savage, C Szoeke, VL Villemagne, P Maruff

2013-01-01

We aimed to characterize the nature and magnitude of cognitive decline in a group of adults with amnestic mild cognitive impairmen..

Decline in cognitive function over 18 months in healthy older adults with high amyloid-β

KA Ellis, YY Lim, K Harrington, D Ames, AI Bush, D Darby, RN Martins, CL Masters, CC Rowe, G Savage, C Szoeke, VL Villemagne, P Maruff

2013-01-01

We aimed to characterize the nature and magnitude of cognitive decline in a group of healthy older adults with high and low levels..

Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease

A Rembach, JD Doecke, BR Roberts, AD Watt, NG Faux, I Volitakis, KK Pertile, RL Rumble, BO Trounson, CJ Fowler, W Wilson, KA Ellis, RN Martins, CC Rowe, VL Villemagne, D Ames, CL Masters, AI Bush

2013-01-01

Background: Several studies have reported that peripheral levels of copper and ceruloplasmin (CP) can differentiate patients with ..

Metallostasis in Alzheimer's disease

S Ayton, P Lei, AI Bush

2013-01-01

2012 has been another year in which multiple large-scale clinical trials for Alzheimer's disease (AD) have failed to meet their cl..

Rapid decline in episodic memory in healthy older adults with high amyloid-β

YY Lim, RH Pietrzak, KA Ellis, J Jaeger, K Harrington, T Ashwood, C Szoeke, RN Martins, AI Bush, CL Masters, CC Rowe, VL Villemagne, D Ames, D Darby, P Maruff

2013-01-01

High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy olde..

Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS)

YY Lim, J Jaeger, K Harrington, T Ashwood, KA Ellis, A Stöffler, C Szoeke, R Lachovitzki, RN Martins, VL Villemagne, A Bush, CL Masters, CC Rowe, D Ames, D Darby, P Maruff

2013-01-01

Large prospective studies of Alzheimer's disease (AD) have sought to understand the pathological evolution of AD and factors that ..

Zinc in Alzheimer’s and Parkinson’s Diseases

S Ayton, DI Finkelstein, RA Cherny, AI Bush, PA Adlard

2013-01-01

Characterization of the role of etallothionein-3 in an animal model of Alzheimer's disease

Y Manso, J Carrasco, G Comes, G Meloni, PA Adlard, AI Bush, M Vašák, J Hidalgo

2012-11-01

Among the dementias, Alzheimer's disease (AD) is the most commonly diagnosed, but there are still no effective drugs available for..

Blood-based protein biomarkers for diagnosis of Alzheimer disease

JD Doecke, SM Laws, NG Faux, W Wilson, SC Burnham, CP Lam, A Mondal, J Bedo, AI Bush, B Brown, K De Ruyck, KA Ellis, C Fowler, VB Gupta, R Head, SL Macaulay, K Pertile, CC Rowe, A Rembach, M Rodrigues

2012-10-01

Objective: To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD). Design: Baseline plasma screening of 151 mul..

Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

M Berk, OM Dean, SM Cotton, CS Gama, F Kapczinski, B Fernandes, K Kohlmann, S Jeavons, K Hewitt, K Moss, C Allwang, I Schapkaitz, H Cobb, AI Bush, S Dodd, GS Malhi

2012-08-14

Background: N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-co..

Alterations in brain transition metals in Huntington disease: An evolving and intricate story

HD Rosas, YI Chen, G Doros, DH Salat, NK Chen, KK Kwong, A Bush, J Fox, SM Hersch

2012-07-01

Background: Aberrant accumulation of transition metals in the brain may have an early and important role in the pathogenesis of se..

P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid

BJ Gu, JA Duce, VA Valova, B Wong, AI Bush, S Petrou, JS Wiley

2012-05-18

Rapid phagocytosis of non-opsonized particles including apoptotic cells is an important process that involves direct recognition o..

The hypoxia imaging agent Cu ii(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

LW Hung, VL Villemagne, L Cheng, NA Sherratt, S Ayton, AR White, PJ Crouch, SC Lim, SL Leong, S Wilkins, J George, BR Roberts, CLL Pham, X Liu, FCK Chiu, DM Shackleford, AK Powell, CL Masters, AI Bush, G O'Keefe

2012-04-09

Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia, rigidity, instability, and tremors. The di..

Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.

Paul Anthony Adlard, Ashley Ian Bush

2012-03-02

As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important t..

Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese

G McColl, SA James, S Mayo, DL Howard, CG Ryan, R Kirkham, GF Moorhead, D Paterson, MD de Jonge, AI Bush

2012-02-29

Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack..

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

P Lei, S Ayton, DI Finkelstein, L Spoerri, GD Ciccotosto, DK Wright, BXW Wong, PA Adlard, RA Cherny, LQ Lam, BR Roberts, I Volitakis, GF Egan, CA McLean, R Cappai, JA Duce, AI Bush

2012-02-01

The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and Parkinson's disease and mutations that ca..

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

SA James, I Volitakis, PA Adlard, JA Duce, CL Masters, RA Cherny, AI Bush

2012-01-15

Oxidative stress is implicated in Alzheimer disease (AD) pathogenesis, for which evidence indicates that radical species are gener..

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

Y Manso, J Carrasco, G Comes, PA Adlard, AI Bush, J Hidalgo

2012-01-01

Alzheimer's disease (AD) is by far the most commonly diagnosed dementia, and despite multiple efforts, there are still no effectiv..

The role of metallobiology and amyloid-β peptides in Alzheimer's disease

BR Roberts, TM Ryan, AI Bush, CL Masters, JA Duce

2012-01-01

The biggest risk factor for Alzheimer's disease is the process of ageing, but the mechanisms that lead to the manifestation of the..